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Bone and Cartilage Regeneration Products from Harvard Healthcare

Our Bone and Cartilage Regeneration products are supplied by Geistlich Surgery

Geistlich Surgery is a leading specialist with a focus in bone and cartilage regeneration. Natural scaffolds and matrices from Geistlich Surgery help to regenerate missing structures in the human body - today and in the future!

Bone regeneration with Orthoss natural bone substitute material: 20 years of clinical experience and success in orthopaedic and trauma surgery 
 
Due to its natural origin, Orthoss® displays a high degree of similarity to human bone. This accounts for the excellent osteoconductivity of Orthoss® and allows the participation of Orthoss® in the natural remodelling process of the bone. Synthetic bone replacement materials, such as Tricalciumphosphate(TCP) or glass granules, are different from bone in their structure and composition.

Allogenic bone (bone bank) is frequently used for bone replacement and regeneration. The application of autologous bone is limited by its availability and additional stress to the patient through secondary operations and donor site morbidity. Homologous bone carries immunological risks, as well as the risk of infection from bone in their construction and composition are not incorporated during the natural reconstruction process of the bone. With the development of Orthoss® , an alternative bone replacement material is available, in which the natural inorganic, hydroxyapatite-based bone structure is maintained. Orthoss® is supporting the natural remodelling process of the bone by offering a matrix for osteoblasts.
Orthoss shows best clinical results when it is used as a volume expander for autologous bone in different orthopaedic procedures.

In the production of Orthoss® , proteins from bovine bone are removed in a patented procedure, and the original properties of the natural mineral structure remain largely unchanged.

Orthoss Applications
Orthoss Publications

Cartilage Regeneration using AMIC: a new biological cartilage repair method

AMIC® (Autologous Matrix Induced Chondrogenesis) is new biological cartilage repair method. This innovative technique uses the body's own healing potential and the regenerative capacity of Mesenchymal Stem cells. It can be applied to cartilage defects that extend full thickness down to the subchondral bone and are bigger than 1-2 cm2. The AMIC® technique is based on proven biological concepts first demonstrated by Richard Steadman with his microfracture method. The shortcoming with microfracture is that it only appears to be able to regenerate fibrocartilage and not Hyaline cartilage which is much stiffer and more resistant to shear forces. AMIC® differs from microfracture in that a cover, in the form of the Chondro-Gide® collagen matrix, is applied over the defect immediately following microfracture. This cover then traps the first few millilitres of bone marrow bleeding which contain the highest percentage of mesenchymal stem cells to form a so called &lsquo Superclot&rsquo . In so doing the first and most important clot is kept in place and not lost into the joint as so often happens with microfracture.The Chondro-Gide® collagen matrix forms the roof of a 'biological chamber' and serves to protect and contain the stem cells as they differentiate into chondrocytes, which will form a healthy regenerative cartilage.

Chondro-Gide bilayer Collagen I/III Matrix
Chondro-Gide Publications
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